Dr. Kleinman has more than 60 articles in peer-reviewed journals and over 90 conference presentations. His publications focus on real-world healthcare data, including medical economics, treatment adherence, and the impact of social determinants on health outcomes. His work appears in respected journals such as the Journal of Clinical Psychiatry as well as the Journal of Medical Economics and other leading outlets in the field. Dr. Kleinman’s research is widely recognized for its practical impact on healthcare decision-making and policy.
Humes HD, Kleinman N, Kammerer J, et al. Projected hospitalization cost impact of the selective cytopheretic device in pediatric acute kidney injury. J Med Econ. Published online August 23, 2025. doi:10.1080/13696998.2025.2550860
Brook RA, Seo S, Beren IA, et al. The impact of health benefit design on patients with infertility. Am J Manag Care. 2025;31(8):e221-e227. Published 2025 Aug 1. doi:10.37765/ajmc.2025.89777
Judy J, Yehoshua A, Gouveia-Pisano J, et al. Impact of COVID-19 on work loss in the United States- A retrospective database analysis. J Med Econ. 2024;27(1):941-951. doi:10.1080/13696998.2024.2379056
Kleinman N, Kammerer J, Thakar C. Heart Failure and Edema Costs in Patiromer and Sodium Zirconium Cyclosilicate Users. Kidney360. 2024;5(8):1101-1105. doi:10.34067/KID.0000000000000483
Hendin B, Brook RA, Beren IA, et al. The Clinical and Economic Impact of Employees Who Are Care Partners of Patients with Multiple Sclerosis by Disease Severity. J Health Econ Outcomes Res. 2023;10(1):91-101. Published 2023 Apr 13. doi:10.36469/001c.57593
Tai LJ, Day JW, Munoz KA, Chen CY, Brook RA, Kleinman NL, McEvoy B, Stahl M. Myotonic Dystrophy Patient Journey: Increased Use of Healthcare Resources in the Year Prior to Diagnosis as Evidenced by Insurance Claims. Int J Rare Dis Orph Drugs. 2023;6(2):1017.
Kleinman N, Kammerer J, LaGuerre K, Thakar CV. Social determinants of patiromer adherence and abandonment: An observational, retrospective, real-world claims analysis. PLoS One. 2023 Mar 2718(3):e0281775. doi: 10.1371/journal.pone.0281775.
Brook RA, Kleinman NL, Beren IA. Employer Disability and Workers’ Compensation Trends for Their Employees With Ophthalmic Conditions in the United States. Am Health Drug Benefits. 2023. Web Exclusives published in Business, Original Research. Available at https://www.ahdbonline.com/web-exclusives/3278-employer-disability-and-workers-compensation-trends-for-their-employees-with-ophthalmic-conditions-in-the-united-states.
Hendin B, Brook RA, Beren IA, et al. The Clinical and Economic Impact of Employees Who Are Care Partners of Patients with Multiple Sclerosis by Disease Severity. JHEOR. 202310(1):91-101. doi:10.36469/001c.57593.
Brook RA, Beren IA, Kleinman NL. Employer Paid Sick Leave, Disability, and Workers’ Compensation Trends for Employees Whose Spouses have Cancer Conditions in the United States. J Oncol Res Ther. 20227:10143. DOI: https://doi.org/10.29011/2574710X.010143.
Brook RA, Beren IA, Kleinman NL. Employer Paid Sick Leave, Disability, and Workers’ Compensation Trends for Employees With Cancer Conditions in the United States. J Oncol Res Ther. 20227:10142. DOI: https://doi.org/10.29011/2574-710X.010142.
Brook RA, Kleinman NL, Beren IA. Rheumatoid Arthritis Disability and Absence Trends in the United States. J Biomed Res Environ Sci. 2021 Dec 282(12):1238-1245. DOI: 10.37871/jbres1378.
Brook RA, Kleinman NL, Beren IA. Disability and workers’ compensation trends for employees with mental disorders and SUDs in the United States. Mental Health Clinician. 202111(5):279-286. DOI: 10.9740/mhc.2021.09.279.
Kuvadia H, Beren IA, Starr HL, Sheehan JJ, Kleinman NL, Brook RA. Direct and Indirect Costs Among Caregivers of Patients With Major Depressive Disorder and Suicidal Ideation or Suicidal Attempt. Prim Care Companion CNS Disord. 2021 Aug 1223(4):20m02893. doi: 10.4088/PCC.20m02893.
Shamanna P, Joshi S, Shah L, Dharmalingam M, Saboo S, Mohammed J, Mohamed M, Poon T, Kleinman N, Thajudeen M, Keshavamurthy A. Type 2 diabetes reversal with digital twin technology-enabled precision nutrition and staging of reversal: a retrospective cohort study. Clinical Diabetes and Endocrinology. 20217:21. DOI: 0.1186/s40842-021-00134-7.
Shamanna P, Dharmalingam M, Sahay R, Mohammed J, Mohamed M, Poon T, Kleinman N, Thajudeen M. Retrospective study of glycemic variability, BMI, and blood pressure in diabetes patients in the Digital Twin Precision Treatment Program. Scientific Reports. 202111:14892. DOI: 10.1038/s41598-021-94339-6.
Ribeiro-Oliveira A, Brook RA, Munoz KA, Beren IA, Whalen JD, Kleinman NL, Yuen KCJ. Burden of acromegaly in the United States: Increased health services utilization, location of care, and costs of care. Journal of Medical Economics. 202124(1):432-439. DOI: 10.1080/13696998.2021.1898968.
Shamanna P, Saboo B, Damodharan S, Mohammed J, Mohamed M, Poon T, Kleinman N, Thajudeen M. Reducing HbA1c in type 2 diabetes using digital twin technology-enabled precision nutrition: a retrospective analysis. Diabetes Therapy. 202011:2703-2714. DOI: 10.1007/s13300-020-00931-w.
Baran RW, Samp JC, Walker DR, Smeeding JE, Young JW, Kleinman NL, Brook RA. Costs and Absence of HCV-Infected Employees by Disease Stage. Journal of Medical Economics. 2015.18(9):691-703.
Brook RA, Kleinman NL, Patel S, Smeeding JE, Beren IA, Turpcu A. United States Comparative Costs and Absenteeism of Diabetic Ophthalmic Conditions. Postgraduate Medicine. 2015 Jun.127(5):455-462.
Kleinman NL, Odell K, Chen CI, Atkinson A, Zou KH. Persistence and Adherence with Urinary Antispasmodic Medications among Employees and the Impact of Adherence on Costs and Absenteeism. Journal of Managed Care & Specialty Pharmacy. 2014 Oct.20(10):1047-1056.
Kleinman N, Patel AA, Benson C, Macario A, Kim M, Biondi DM. Economic Burden of Back and Neck Pain: Effect of a Neuropathic Component. Population Health Management. 2014 Aug.17(4):224-232.
Butler R, Kleinman N, Gardner H. I Don’t Like Mondays: Explaining Monday Work Injury Claims. ILR Review. 2014 May.67(3 suppl):762-783.
Kleinman NL, Chen CI, Atkinson A, Odell K, Zou KH. Economic Burden of Urge Urinary Incontinence in the Workplace. Journal of Occupational and Environmental Medicine. 2014 Mar.56(3):266-269.
Kleinman N, Abouzaid S, Andersen L, Wang Z, Powers A. Cohort Analysis Assessing Medical and Nonmedical Cost Associated with Obesity in the Workplace. Journal of Occupational and Environmental Medicine. 2014 Feb.56(2):161-170.
Kleinman NL, Yu H, Beren I, Sato R. The Work-Related and Health Care Cost Burden of Community-Acquired Pneumonia in an Employed Population. Journal of Occupational and Environmental Medicine. 2013.55(10):1149-1156.
Kleinman NL, Rohrbacker NJ, Bushmakin AG, Whiteley J, Lynch WD, Shah S. Direct and Indirect Costs of Women Diagnosed With Menopause Symptoms. Journal of Occupational and Environmental Medicine. 2013 Apr.55(4):465-70.
Kleinman NL, Cifaldi MA, Smeeding JE, Shaw JW, Brook RA. Annual Incremental Health Benefit Costs and Absenteeism among Employees With and Without Rheumatoid Arthritis. Journal of Occupational and Environmental Medicine. 2013.55(3):240-244.
Lynch W, Chan W, Kleinman N, Andrews LM, Yadao AM. Economic Burden of Gouty Arthritis Attacks for Employees with Frequent and Infrequent Attacks. Population Health Management. 2013 Apr.16(2):138-45.
Butler RJ, Kleinman NL, Gardner HH. Workers’ Compensation: Occupational Injury Insurance’s Influence on the Workplace. In: Dionne G, ed. Handbook of Insurance 2nd Edition. New York: Springer 2013. ISBN: 978-1-4614-0154-4.
Brook RA, Kleinman NL. Human Capital Costs and Absenteeism among Employees with Various Conditions. In: Rizzo MF, Gallo A, eds. Human Capital and Resources: Developments, Management and Strategies. Hauppauge, NY: Nova Science Publishers, Inc. 2012:33-60. ISBN: 978-1-61470-898-8.
Kleinman NL, Brook RA. Objectively Measured Work Output (Productivity) among Employees with Various Health Conditions. In: Rizzo MF, Gallo A, eds. Human Capital and Resources: Developments, Management and Strategies. Hauppauge, NY: Nova Science Publishers, Inc. 2012:125-142. ISBN: 978-1-61470-898-8.
Kleinman NL, Sadosky A, Seid J, Martin RC, Labiner DM. Costs, Work Absence, and Adherence in Patients with Partial Onset Seizures Prescribed Gabapentin or Pregabalin. Epilepsy Research. 2012.102(1):13-22.
Brook RA, Kleinman NL, Choung RS, Smeeding JE, Talley NJ. Excess comorbidity prevalence and cost associated with functional dyspepsia in an employed population. Digestive Diseases and Sciences. 2012.57(1):109-118.
Brook RA, Kleinman NL, Su J, Corey-Lisle P, Iloeje UH. Absenteeism and Productivity Impact of Treatment among Employees with Hepatitis-C. American Journal of Managed Care. 2011.17(10):657-664.
Kleinman NL, Sanchez RJ, Lynch WD, Cappelleri JC, Beren IA, Joshi AV. Health Outcomes and Costs among Employees with Fibromyalgia Treated with Pregabalin vs. Standard of Care. Pain Practice. 2011.11(2):1-12.
Kleinman NL, Rohrbacker NJ, White SA, March JL, Reynolds MR. Economic Impact to Employers of Treatment Options for Cardiac Arrhythmias in the US Health System. Journal of Occupational and Environmental Medicine. 2011.53(4):405-414.
Rajagopalan K, Brook RA, Beren IA, Kleinman NL. Comparing Costs and Absences for Multiple Sclerosis among US Employees: Pre and Post Treatment Initiation. Current Medical Research and Opinion. 2011.27(1):179-188.
Kleinman NL, Beren IA, Rajagopalan K, Brook RA. Medication Adherence with Disease Modifying Treatments for Multiple Sclerosis among US Employees. Journal of Medical Economics. 2010.13(4):633-640.
Su J, Brook RA, Kleinman NL, Corey-Lisle P. The Impact of Hepatitis C Virus Infection on Work Absence, Productivity, and Healthcare Benefit Costs. Hepatology. 2010.52:436-442.
Brook RA, Kleinman NL, Choung RS, Melkonian AK, Smeeding JE, Talley NJ. Functional dyspepsia impacts absenteeism and direct and indirect costs. Clinical Gastroenterology and Hepatology. 2010.8(6):498-503.
Rohrbacker NJ, Kleinman NL, White SA, March J, Reynolds MR. The Burden of Atrial Fibrillation and Other Cardiac Arrhythmias in an Employed Population: Associated Costs, Absences, and Objective Productivity Loss. J Occup Environ Med. 2010.52(4):383-391.
Kleinman N, Harnett J, Melkonian A, Lynch WD, Kaplan-Machlis B, Silverman SL. Burden of Fibromyalgia and Comparisons with Osteoarthritis in the Workforce. J Occup Environ Med. 2009.51(12):1384-1393.
Kleinman N, Durkin M, Melkonian A, Markosyan K. Incremental Employee Health Benefit Costs, Absence Days, and Turnover among Employees with ADHD and among Employees with Children with ADHD. J Occup Environ Med. 2009.51(11):1247-1255.
Lynch W, Markosyan K, Melkonian A, Pesa J, Kleinman N. Impact of antihypertensive medication adherence in employees with hypertension. Am J Managed Care. 2009.15(12):871-880.
Kleinman N, Brook R, Doan J, Melkonian A, Baran R. Health Benefit Costs and Absenteeism due to Insomnia from the Employer’s Perspective: A Retrospective, Case-Control, Database Study. Journal of Clinical Psychiatry. 2009.70(8):1098-1104.
Kleinman NL, Brook RA, Ramachandran S. An employer perspective on annual employee and dependent costs for pediatric asthma. Ann Allergy Asthma Immunol. August 2009.103:114–120.
Brook RA, Rajagopalan K, Kleinman NL, Melkonian AK. Absenteeism and Health Benefit Costs Among Employees with Multiple Sclerosis. Curr Med Res Opin. May 2009.25(6):1469–76.
Kleinman N, Melkonian A, Borden S, Rohrbacker N, Lynch W, Gardner H. The impact of morbid obesity and bariatric surgery on comorbid conditions: A comprehensive examination of comorbidities in an employed population. Journal of Occupational and Environmental Medicine 2009.51(2):170-179.
Kleinman N, Schaneman J, Lynch W. The association of insulin medication possession ratio, use of insulin glargine, and health benefits costs in employees and spouses with type 2 diabetes. Journal of Occupational and Environmental Medicine 2008.50:1386-1393.
Wahlqvist P, Brook RA, Campbell SM, Wallander M-A, Alexander AM, Smeeding JE, Kleinman NL. Objective measurement of work absence and on-the-job productivity: a case-control study of US employees with and without gastroesophageal reflux disease. J Occup Environ Med. 2008.50:25-31.
Brook RA, Wahlqvist P, Kleinman NL, Wallander M-A, Campbell SM, Smeeding JE. Cost of gastro-oesophageal reflux disease to the employer: a US perspective. Aliment Pharmacol Ther. 2007.26(6):889-898.
Kleinman NL, Brook RA, Patel PA, Melkonian AK, Brizee TJ, Smeeding JE, Joseph-Ridge N. The impact of gout on work absence and productivity. Value Health. Jul-Aug 2007.10(4):231–237.
Brook RA, Kleinman NL, Rajagopalan K. Employee costs before and after treatment initiation for bipolar disorder. Am J Manag Care. Apr 2007.13(4):179-186.
Novak S, Melkonian AK, Patel PA, Kleinman NL, Joseph-Ridge N, Brook RA. Prevalence of gout with comorbid metabolic and cardiovascular conditions and medical services associated with these conditions in a managed care setting. Curr Med Res Opin. Mar 2007.23(3):623-630.
Gardner H, Kleinman N, Brook R, Rajagopalan K, Brizee T, Smeeding J. The impact of bipolar disorder on an employed population. Journal of Clinical Psychiatry 2006.67:1209-1218.
Brook R, Kleinman N, Patel P, Melkonian A, Brizee T, Smeeding J, Joseph-Ridge N. The economic burden of gout on an employed population. Current Medical Research and Opinion 2006.22(7):1381-1389.
Rajagopalan K, Kleinman N, Brook R, Gardner H, Brizee T, Smeeding J. Costs of physical and mental comorbidities among employees: A comparison of those with and without bipolar disorder. Current Medical Research and Opinion 2006.22(3):443-452.
Erwin G, Iyer S, Rajagopalan R, Astuto J, Wilson P, Schaneman J, Kleinman N. Type 2 diabetes treatment patterns and healthcare costs in the elderly population. Disease Management & Health Outcomes 2006.14(2):75-83.
Brook R, Rajagopalan K, Kleinman N, Smeeding J, Brizee T, Gardner H. Incurring greater health care costs: Risk stratification of bipolar disorder employees. The Primary Care Companion to the Journal of Clinical Psychiatry 2006.8(1):17-24.
Kleinman N, Brook R, Rajagopalan K, Gardner H, Brizee T, Smeeding J. Lost time, absence costs, and reduced productivity output for employees with bipolar disorder. Journal of Occupational and Environmental Medicine 2005.47(11):1117-1124.
Gardner HH, Kleinman N, Butler RJ. Waiting periods and health-related absenteeism: The need for program integration. Benefits Quarterly, Volume 16, Number 3, Third Quarter 2000.
Gardner HH, Kleinman N, Butler RJ. Workers’ compensation and family and medical leave act claim contagion. The Journal of Risk and Uncertainty 2000.20:89-112.
Kleinman N, Spall J, Naiman D. Simulation-based optimization with stochastic approximation using common random numbers. Management Science 1999.45:1570-1578.
Kleinman N, Hill S, Ilenda V. Simulation optimization of air traffic delay cost. Proceedings of the 1998 Winter Simulation Conference, D.J. Medeiros, E.F. Watson, J.S. Carson, and M.S. Manivannan, eds., pp. 1177-1181.
Kleinman N. Stochastic approximation algorithms: Theory and application. Dissertation. The Johns Hopkins University, 1997.
Kleinman N, Hill S, Ilenda V. SPSA/SIMMOD optimization of air traffic delay cost. Proceedings of the American Control Conference, Albuquerque, New Mexico, June 1997, pp 1121–1125.
Smith R, Chin D, Kleinman N. Evaluation of a real-time, non-network-model-based traffic signal control technique in the presence of long-term trends. Proceedings of the 1995 Annual Meeting of ITS America, volume 1, pages 633-638. Intelligent Transportation Society of America, 1995.
Kleinman N. “NN/SPSA traffic controller modifications and simulations.” Technical Report #PSA-94-130. Applied Physics Laboratory of the Johns Hopkins University. October 28, 1994.